How do you counsel patients who are considering stopping a GLP-1 agonist after achieving their weight loss goal, now that long-term maintenance data suggest most will regain a substantial portion of their weight within a year of discontinuation?

Great question! I actually incorporate this knowledge into my initial medication counseling to see whether patients are comfortable being on this medication chronically. I let almost everyone know that coming off the medication will likely lead to significant weight gain, and that comes with signifi...