Do you immediately discontinue sulfonylureas when initiating GLP-1 receptor agonists in patients with longstanding type 2 diabetes?

In a patient with an A1c <8% or with current issues with hypoglycemia while taking a sulfonylurea (SU), I would discontinue the sulfonylurea at the time I prescribe any highly effective medication for type 2 diabetes, including a GLP-1-based therapy. That would be with instructions to the patient to...

It is an interesting question. Sulfonylureas are old-established drugs for the treatment of diabetes, although they are becoming less popular due to their risk of hypoglycemia and the fact that there are now better drugs available for the management of hyperglycemia of diabetes. GLP-1 receptor agoni...