Do you ever combine voclosporin and belimumab in the treatment of lupus nephritis?

The combination of these two therapies has not yet been formally tested. Having said that, the combination has an appealing rationale. Immunologically, modulating T cells and B cells in LN seems likely to be efficacious. Beyond the immunology, there are other reasons that favor this combination. Voc...

I have not used the combination of voclosporin and belimumab, but several have suggested administering voclosporin early on to take advantage of its rapid effects. After the initial period, one could then add Belimumab to take advantage of its long-term benefits.

Patients with LN are typically young...

I agree with @Dr. First Last's comments regarding a rationale for combining voclosporin, a CNI, with belimumab, and B cell antagonist. There is small published case series from Johns Hopkins reporting on using them together in 4 patients. (Baum et al., PMID 37303434) Major observation of report is p...