Do you ever start with lower than standard doses of TKIs when initiating treatment for chronic phase CML?
For instance, do you ever start with dasatinib 50 mg daily? Are there any titration schedules that you follow?
Answer from: Medical Oncologist at Academic Institution
Not usually with the exception of bosutinib. I specifically start bosutinib at 200 mg and go up by 100 mg every week until the patient is at full dose. I find this helps manage the initial diarrhea associated with the drug. Otherwise, I start at the standard dose for all drugs. I may decrease the do...
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