Do you ever switch to vancomycin after clinical improvement and blood culture clearance in a patient with high grade vancomycin-susceptible MRSA bacteremia in whom a salvage regimen was initiated?   

Several concerns need to be addressed for the de-escalation of intensive, combination treatment of MRSA bacteremia to vancomycin monotherapy for susceptible isolates. Source control is always an important consideration for cure. The review by Rose et al, including multiple studies involving treatmen...