Do you ever switch to vancomycin after clinical improvement and blood culture clearance in a patient with high grade vancomycin-susceptible MRSA bacteremia in whom a salvage regimen was initiated?   

1. Salvage regimen (usually higher dose daptomycin + beta-lactam agent, often, ceftaroline) is used in various scenarios. Persistent bacteremia with: High vancomycin MIC No obvious source The source is obvious, but the source control is not imminently possible or too risky to justify any surgi...

Several concerns need to be addressed for the de-escalation of intensive, combination treatment of MRSA bacteremia to vancomycin monotherapy for susceptible isolates. Source control is always an important consideration for cure. The review by Rose et al, including multiple studies involving treatmen...

This question is potentially confusing because “salvage regimen” is not defined. The first part indicates that there is both clinical and microbiologic improvement, which suggests that the regimen is effective and appropriate. There is no evidence presented that it represents a substanda...