Do you give TNK to patients presenting with transient global amnesia like symptoms within 4.5 hours?

This is a very interesting clinical question that does not come up practically very often. There is next to no study data available on the matter, so most of what I will propose here can be classified as an expert take.

I think that the most direct, and clinically relevant way of approaching such a decision would be similar to any other TNK decision: one must identify whether the deficits currently ailing the patient are disabling to such an extent as to merit taking on the risks of administerin...

TGA is not a stroke. The NIHSS would be about 2, for which the evidence of benefit would be minimal.

In short, yes-depending on the case.

If a patient had a transient episode of anterograde amnesia, however, at the time of exam they have no difficulty with immediate and delayed recall or forming recent memories (over the last 30 minutes) without any other deficits, then the risks may be more than benefits. One thing to remember is the patient, even with a true TGA, will always have retrograde amnesia for the events that occurred when the event was occurring. So most important thing to rember is ...