Do you have any hesitations for combining belimumab with any of the DMARDs in patients with SLE/RA overlap?

The only disease-modifying agents for rheumatic diseases (DMARDs) that I would not use with Benlysta are the Janus kinase inhibitors (tofacitinib, baricitinib, and upadacitinib), which are considered “targeted synthetic DMARDs” (Harrington). We all know these agents to be as strong as biologics. Mos...

I agree with Dr. @Dr. First Last.

I have used belimumab in combination with most DMARDs (Methotrexate, Mycophenolate, Azathioprine, Hydroxychloroquine) without any safety signals (except an increase in UTI and bronchitis rates in my experience). I have avoided combining belimumab with other biologics...