Do you have preferred regimens for young patients (<30 y/o) with early stage DLBCL?
Guidelines indicate RCHOPx3 +RT as category I and RCHOP x 6 below that; long term f/u for SWOG 8736 showed similar PFS and OS. Do you have and approaches to decide on toxicity vs benefit of different options in younger patients?
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · Duke University Medical Center
Answered on
For patients with early-stage, non-bulky disease, 3 cycles of R-CHOP + ISRT (30 Gy) provides excellent outcomes. This strategy is particularly attractive if the site(s) of disease requiring irradiation would engender a very low risk of late effects from RT (e.g., an inguinal lymph node). In the rand...
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