Do you have to extend treatment for acute Lyme disease if a patient is on high dose steroids for another indication?  

I am unaware of any evidence to support longer-term therapy in such a setting. I am quite sure no such study has ever been done. Standard therapy for early Lyme disease is 10 days of appropriate antibiotics. Extending to 20 days would likely do no harm to the patient, but may not be necessary, and t...

There are currently no evidence-based recommendations to extend antibiotic therapy for acute Lyme disease in patients receiving high-dose glucocorticoids or other forms of immunosuppression. The 2020 IDSA/AAN/ACR guidelines do not specifically address management modifications in this setting, a...