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Do you maintain a strict platelet threshold of >50k when performing a lumbar puncture, or are there situations in which you feel comfortable with a lower threshold?  

While many US guidelines have supported a threshold of > 50k, there does not appear to be robust data to support it. Notably, the 2025 AABB and ICTMG International Clinical Practice Guidelines recommend a lower cutoff of <20k for pre-procedural platelet transfusion.



Answer from: at Academic Institution
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at Providence Santa Rosa Pulmonary Disease
This may be one of those situations where it is "t...
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