Do you modify your neoadjuvant considerations for patients with micropapillary histology and pT2 urothelial carcinoma and no distant neoplastic disease?

No. The prognostic significance of this histology is uncertain (EAU Systematic Review, Veskimae et al., Eur Urol Onc 2019). Prospective well powered studies with overall survival as the primary outcome and which incorporate disease classifiers that are more accurate than histology (e.g. a molecular ...