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Do you offer consolidation chemotherapy prior to durvalumab in locally advanced, unresectable NSCLC?

In clinical practice, consolidation chemotherapy is sometimes used, though this was not implemented in the PACIFIC trial. Antonia et al., PMID 28885881
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Do you offer consolidation chemotherapy prior to durvalumab in locally advanced, unresectable NSCLC?

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3 Answers
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Medical Oncology · Indiana University School of Medicine
Answered on

I do not offer consolidation chemotherapy to patients prior to durvalumab in patients with locally advanced, unresectable NSCLC. The PACIFIC trial was a randomized phase III trial that established the role of consolidation durvalumab after definitive chemoradiation for patients with stage III NSCLC....

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Medical Oncology · Cedars-Sinai Medical Center
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Despite several approaches to improve outcomes for patients with unresectable stage III NSCLC over the past decades, none have been shown to increase survival before the addition of consolidation durvalumab in the PACIFIC trial. The addition of consolidation chemotherapy was shown to lead to increas...

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Medical Oncology · Wexner Medical Center at The Ohio State University
Answered on

Ever since the publication of the PACIFIC trial which allowed “induction” chemotherapy prior to chemoradiation but no “consolidation” chemotherapy, I have not been using consolidation chemotherapy. Given that the last 25+ years have barely (if at all) moved the needle (with induction, consolidation,...

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