Do you offer consolidative thoracic radiotherapy to patients with extensive stage SCLC who have a complete response to chemotherapy?

Topics: Radiation Oncology • Thoracic Malignancies

If so, what fields do you irradiate? The initially involved nodal regions? Do you offer after PR as well? If not, do you consolidate at any point in the future (ie after a local recurrence, after response to second line treatment, only for palliation, etc.)?

Answer from: Radiation Oncologist at Community Practice

The CREST trial did not meet primary goal of improving one year survival, but it did improve 2 year OS. Looking at subset, achieving CR to chemo was an indicator of a group that "did not benefit". So the rest of the question (what volume, what dose etc) becomes irrelevant.

Comments

Radiation Oncologist at Generations Radiotherapy and Oncology PC
@Andrew T. Turrisi, was the subset to which you re...

Answer from: Radiation Oncologist at Academic Institution

Overall, my clinical practice mirrors that of Dr. @Andrew T. Turrisi's answer based on subset analysis of the CREST trial suggesting that the patients who benefited the most were those with only a partial response in the chest, these are not full independent publications but rather information prese...

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