Do you offer consolidative thoracic radiotherapy to patients with extensive stage SCLC who have a complete response to chemotherapy?
If so, what fields do you irradiate? The initially involved nodal regions? Do you offer after PR as well? If not, do you consolidate at any point in the future (ie after a local recurrence, after response to second line treatment, only for palliation, etc.)?
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Do you offer consolidative TRT for ES-SCLC?
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2 Answers
Mednet MemberInvited Expert
Radiation Oncology · Quillen VA Medical Center
Answered on
The CREST trial did not meet primary goal of improving one year survival, but it did improve 2 year OS. Looking at subset, achieving CR to chemo was an indicator of a group that "did not benefit". So the rest of the question (what volume, what dose etc) becomes irrelevant.
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Mednet MemberInvited Expert
Radiation Oncology · Cleveland Clinic
Answered on
Overall, my clinical practice mirrors that of Dr. @Dr. First Last's answer based on subset analysis of the CREST trial suggesting that the patients who benefited the most were those with only a partial response in the chest, these are not full independent publications but rather information presente...
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