Do you offer memantine for cognitive preservation to glioma patients?

I do not as there is currently no evidence to support this. There was a trial conducted by the RTOG for whole brain RT patients with mets which demonstrated a trend towards improvement in time to cognitive decline (53.8 % at 24 weeks for memantine vs 64.9 % for placebo), executive function at 8 and 16 weeks, processing speed, and delayed recognition at 24 weeks. I think this is an area that needs more research and until more data is presented, no definitive conclusions can be made.