The available data would suggest a very small benefit, if at all, for anthracyclines in the locally advanced setting.Although the MAGIC study established ECF as a standard-of-care, a contemporaneous French FFCD study revealed nearly identical outcomes with 5-FU/cisplatin alone.More recently, the res...

I agree completely with Dr Ku and in fact have never administered epirubicin with any platinum/fluoropyrimidine combination despite the level 1 evidence from MAGIC.  Sometimes trials just answer the wrong question... I think it's perfectly acceptable to give a platinum/fluoropyrimidine combina...