Do you perform EMG and repetitive nerve stimulation in patients with ocular myasthenia gravis, particularly those who are AChR-positive, to assess for electrophysiological evidence of generalized disease?

There is already quite some literature about this question. I have included a recent reference that identified the predictors of generalization of ocular MG in 122 patients evaluated over 24 years in Malaysia. To summarize, in multivariate analysis, positive anti-AChR antibodies, positive RNS (OR 4....

The question is, do patients with ocular MG have electrodiagnostic evidence of abnormal neuromuscular transmission in limb muscles? The answer is, yes. Thus, the definition of Ocular MG is based on the clinical findings, not the electrodiagnostic findings.

In our experience, the majority of patients ...