Do you prefer telmisartan over other ARBs given its longer half life elimination?
Do you prefer telmisartan over other ARBs given its longer half life elimination?
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When considering a specific medication within a class, I try to take into account: cost, side effects, efficacy, pharmacodynamics, and long-term compliance. In regard to pharmacodynamics, I am trying to maximize the duration of action. This often, but not always, correlates with drug half-life. For example, the half-life of spironolactone is up to 35 hours for its active metabolites but in trials, we've observed the duration of action to be as long as 6 weeks. The duration of action represents t...
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There is some evidence to suggest that telmisartan does better in controlling BP, especially in the last few hours prior to the next dose (AM pre-med BP) and when added to a thiazide may have better BP control than other ARB. However, the challenge I often face is insurance approval and therefore gravitate towards losartan or valsartan.
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