Do you recommend a "washout" period for anti-CGRP medications before conception?

Wise advice from Dr. @Dr. First Last. We are presenting a talk at AHS demonstrating that women who conceive on monoclonal antibodies have an elevated risk of spontaneous abortion in the first trimester. Remember that 50% of pregnancies are unplanned. I advise women on CGRP-targeted therapies to be o...

The CGRP-targeted medications come in two groups: gepants and CGRP antibodies. The half-life of the gepants lies in the order of magnitude of 5-10 hours, which means that they are out of the body in roughly 3 days. The half-life of the CGRP antibodies is about a month, which means that it takes 5 mo...

I recommend waiting 5 months to start planning conception after stopping CGRP monoclonal antibodies. For gepants, I recommend waiting 5 days.