Do you recommend ADT or other systemic therapy in patients with rising PSA after prostatectomy and salvage RT and PSMA scan negative for metastatic disease?
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2 Answers
Mednet Member
Medical Oncology · University of Minnesota–Masonic Cancer Center
Generally, I do not recommend systemic therapy for such patients. If doing so, it would be intermittent ADT (alone) for 6-or 9-month cycles. The EMBARK study will hopefully address this important question.
Mednet Member
Medical Oncology · Mary Lanning Healthcare Morrison Cancer Center/University of Nebraska Medical Center Adjunct Faculty
Look at the patient life expectancy, PSA velocity, PSA doubling time, initial stage, Gleason's grade group, PSA level at the time of definitive therapy when deciding whether to begin ADT in this setting.
If life expectancy is less than 5 years, if PSA doubling time is more than 12 months, consider ob...