Do you recommend concurrent or sequential radiation and chemotherapy for margin-positive, node negative NSCLC?

We recently looked at outcomes with sequencing of PORT and chemotherapy in patients with pN2 disease and R0, or pN2 R1/R2 resection in the NCDB (J Clin Oncol 2017 Dec 13:JCO2017744771). This group is not exactly the pN0 patient population that is the focus of this question, however, in the R0 pN2 gr...

I agree overall. The key here is, as Dr K points out, is that a positive margin is fairly rare for node negative patients. There's not any direct prospective data that addresses the question, so we're stuck extrapolating. We had a case recently and this is the way we approached it:

The first option ...