Do you recommend continuous antibiotic prophylaxis for patients on complement inhibitors such as eculizumab?

This is an extremely important and timely question. There simply isn’t enough data or firm guidelines on this leading to different practices. The reality is that there have been a number of meningococcal breakthrough infections in those vaccinated against meningococcal disease. Complement therapies ...

In my practice, I do NOT prescribe antibiotics routinely to patients treated with eculizumab, but, that said, I understand the approach proposed by Drs. @Dr. First Last Silversteen and @Dr. First Last, because the patient population I treat is different; I use it only in neuromuscular patients with ...

I agree with the perspective provided by Dr. @Dr. First Last most especially that, although infrequent, breakthrough infections with meningococcus have occurred despite vaccination with ACWY and B vaccines. My experience with Eculizumab and Ravulizumab includes patients with SLE or SLE with CAPS and...