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Do you recommend doxycycline over azithromycin as first-line treatment for outpatient community-acquired pneumonia in otherwise healthy adults, given rising macrolide resistance rates?

Gupta et al., PMID 34250183
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Do you recommend doxycycline over azithromycin as first-line treatment for outpatient community-acquired pneumonia in otherwise healthy adults?

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1 Answer
Mednet Member
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Infectious Disease · UT Southwestern School of Medicine
Answered on

Yes - our county antibiogram shows >50% resistance of Streptococcus pneumoniae to azithromycin, and thus if there is a true concern for bacterial infection, I recommend doxycycline.

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