Do you recommend GLP-1s for antispychotic induced weight gain?

When antipsychotic induced weight gain causes obesity (BMI>30), I recommend a trial of tirzepatide or semaglutide. I have observed the typical benefits in my patients, including decreases in lipids, lower HgbA1c, lower BPs, improved mobility, and loss of 10-20% of body weight over 6 months. Expense ...

I would generally refer to the PCP for this discussion and a prescription, but I would always bring up GLP-1s as an option to consider. Of course, I would recommend first increasing physical activity, Mediterranean diet strategies, and sleep hygiene. But we do make patients' jobs harder with our med...

This is a compelling clinical question, particularly as the evidence base continues to rapidly evolve.

Many highly effective antipsychotics unfortunately induce severe metabolic dysfunction through their molecular pathways, and GLP-1 receptor agonists offer a powerful therapeutic counterweight to thi...