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Topics:
Infectious Disease • General Infectious Disease
Do you recommend low or intermediate dosing of TMP-SMX over high dosing for the initial treatment of non-disseminated pulmonary nocardiosis?
Yetmar et al., PMID 38922564
High dose: > 10 mg/kg/day
Intermediate dose: 5-10 mg/kg/day
Low dose: < 5 mg/kg/day
Answer from: at Community Practice
I would use low or intermediate dosing for non-disseminated pulmonary nocardiosis. I am not familiar with evidence supporting high-dose in this setting, and a retrospective review from investigators from the Mayo clinic sites last year showed similar outcomes (Yetmar et al., PMID 38922564). High-dos...
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