Do you recommend post-mastectomy RT for a premenopausal woman with ER/PR+ Her2 negative breast cancer and Li-Fraumeni syndrome with RCBII and residual disease in multiple LNs following neoadjuvant chemotherapy?  

I have been very reluctant to offer RT for patients with Li-Fraumeni syndrome as in limited published data, the risk of RT-induced second malignancy can be as high as 25%. Any potential benefit has to be weighed against the risk. In the above case, need to look at the entire clinical scenario and qu...