While we cannot conscientiously recommend this YET, I do not think it is necessarily contraindicated. I would not use it in conjunction with tolvaptan, but I think the results of the UC Denver trial will be informative. It may indeed be as useful for PKD patients as in other CKD patients, including ...

Of course, more data is needed, but from the start, I would hold off for now, and would try other evidence-based interventions first (i.e., diet, strength training, anti-diabetics like metformin). Personally, I believe SGLT2i may be used along with GLP-1, however, we should wait for data to help us ...