Do you recommend starting an antiplatelet for primary prophylaxis in post splenectomy thrombocytosis given there is some increased risk of venous thrombosis?
If so, what platelet count threshold would you use? Would age impact your decision? Would you do a bone marrow to rule out primary MPD in adults if they test negative on blood for JAK2 with reflex to Exon 12-14, CALR and MPL mutations?
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Do you start an antiplatelet for primary prophylaxis in post splenectomy thrombocytosis?
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Hematology · Johns Hopkins University
Answered on
I do not recommend routinely initiating prophylactic antiplatelet therapy for post splenectomy thrombocytosis. First, in patients without a myeloproliferative neoplasm (MPN), the increase in platelet number post splenectomy is both delayed and mild, and there is no correlation between reactive throm...
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