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Do you recommend testing for G6PD deficiency in those with whom rasburicase for tumor lysis syndrome is indicated?

2 Answers
Mednet Member
Mednet Member
Nephrology · Memorial Sloan Kettering Cancer Center

G6PD deficiency is a contraindication to the use of rasburicase and should be tested for prior to the use of this drug.

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Mednet Member
Mednet Member
Nephrology · MD Anderson

You're supposed to test, but most do not. It's X-linked, so males are more susceptible. Certain populations are too: sub-Saharan Africa, the Mediterranean, and Southeast Asia.

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