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Do you recommend vitamin C supplementation with PO iron in patients with iron deficiency?
Is this recommendation given to all patients or only certain patients, and if so, which patients?
Answer from: Medical Oncologist at Academic Institution
Vitamin C supplementation is unnecessary. Taking the iron with a glass of orange juice away from food and especially coffee optimizes absorption. That being said vitamin C does no harm. See vonSiebenthal et al eClinical Works 2023 (Lancet publication), Benson et al, Lancet Haem 2025 or Auerbach et a...
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Answer from: at Academic Institution
Vitamin C can theoretically reduce iron to the ferrous form, making it easier to absorb. I have added Vitamin C in some who do not seem to be responding well to oral iron. Anecdotally, I have not found that to be particularly helpful Some patients read about this effect and ask if they can take it. ...