Do you recommend vitamin C supplementation with PO iron in patients with iron deficiency?

Vitamin C supplementation is unnecessary. Taking the iron with a glass of orange juice away from food and especially coffee optimizes absorption. That being said vitamin C does no harm. See vonSiebenthal et al eClinical Works 2023 (Lancet publication), Benson et al, Lancet Haem 2025 or Auerbach et a...

Vitamin C can theoretically reduce iron to the ferrous form, making it easier to absorb. I have added Vitamin C in some who do not seem to be responding well to oral iron. Anecdotally, I have not found that to be particularly helpful

Some patients read about this effect and ask if they can take it. ...