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Do you routinely check Infliximab levels on day 3 with patients admitted with acute severe ulcerative colitis?

If yes, in which patients do you check, and how does it impact the dosing of infliximab? Are there any patient characteristics that support this strategy? How do you intensify the dose based on the levels if you check it?
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Do check Infliximab levels on day 3 with patients admitted with acute severe ulcerative colitis?

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3 Answers
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Gastroenterology · Icahn School of Medicine at Mount Sinai
Answered on

The question implies that the patient has received the first induction dose of IFX just three days earlier. If that is the case, day 3 seems too soon to check a level. Normally, we might check a trough level just before the second dose in two weeks. If the level is low, we would increase the second ...

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Gastroenterology · Harvard Medical School
Answered on

Conceptually, while this is an important concept, from a practical standpoint, most hospitals do not have a point-of-care IFX assay that can provide levels right away. Most IFX levels in the real world take around a week to come back, which makes that not impactful from a clinical standpoint in acut...

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Gastroenterology · Mayo Clinic
Answered on

I am going to assume, as Dr. @Dr. First Last mentioned, that the patient received an infusion of 5 mg/kg while an inpatient 3 days ago. If the patient has had a clinical response (significant decrease in the number of bowel movements, bleeding) and the CRP has dropped as well, then it is unclear tha...

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