Do you routinely evaluate patients with collagen disorders or Ehlers-Danlos for platelet defects?

Yes, I routinely carry out a full hemostasis evaluation, including platelet aggregation and release studies, in patients referred to me with easy bruising and hypermobility with an increased Beighton score suggesting EDS and in those already diagnosed genetically with EDS. EDS patients typically have an increased bleeding score (Kumskova et al., PMID 37179130). Furthermore, easy bruising is a diagnostic criterion in 9/14 EDS subtypes. (James McFadyen, PMID 41746638).

In 2018, an Italian study sh...