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Do you routinely give prophylactic antibiotics prior to ERCP for biliary obstruction in light of recent studies suggesting a reduction of periprocedural infection?

Leem et al., PMID 37713527 Smith et al., PMID 40961256
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Do you routinely give prophylactic antibiotics prior to ERCP?

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2 Answers
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Hospital Medicine · UT Health San Antonio
Answered on

I did not use to give antibiotics routinely prior to ERCP, and it seemed post-ERCP antibiotics were given at the discretion of the advanced endoscopist, but the results of this meta-analysis will likely change my practice so that I'll give all patients a dose of Ceftriaxone prior to the procedure to...

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Mednet Member
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Hospital Medicine · Emory University Hospital
Answered on

Routine antibiotics prophylaxis is not recommended prior to ERCP, and anticipated incomplete biliary drainage remains the strongest indicator. It is not unreasonable to consider antibiotics prophylaxis in high-risk patients with primary sclerosing cholangitis, cholangiocarcinoma, malignant biliary o...

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