Do you routinely monitor the QTc when adding voclosporin to hydroxychloroquine in a patient with lupus nephritis?

I approach this situation similar to any drug that can potentially prolong QTc intervals when used with hydroxychloroquine (HCQ). [see final comment at the bottom]

Quick answer: No, I do not monitor ECGs (QTc) in patients taking voclosporin (VOC) plus HCQ unless they are at high risk for QTc prolongation complications (patients with a history of cardiac arrhythmia, congenital long QT syndrome, patients with CHF, and patients who have an existing long QT interval, >460 ms in men, > 479 ms in women...