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Do you routinely offer consolidation RT to sites of previous bulky disease in stage III and IV Hodgkin's lymphoma who have a complete metabolic response on restaging PET/CT following 6 cycles of ABVD?

In what situations would you feel comfortable omitting RT to bulky disease in stage III/IV Hodgkin's lymphoma?
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Do you routinely offer consolidation RT to sites of previous bulky disease in stage III and IV Hodgkin's lymphoma with negative post-chemotherapy PET/CT?

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Radiation Oncology · Duke University Medical Center
Answered on · Updated on

Update - 1/5/24

Three important studies have been published in the last few years which shed light on the role of RT in advanced HL in the setting of a negative interim (and post-chemotherapy) PET-CT.

The RATHL trial included 1,119 patients with IIB-IV (or IIA with either bulky disease or at least 3 s...

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