Do you routinely recommend IV systemic antibiotic therapy in additional to intravitreal antibiotic therapy for exogenous bacterial endophthalmitis?

Post-surgical (exogenous) endophthalmitis is an uncommon complication with the incidence ranging from 0.04%-0.3%, 0.019%- 0.54%, and 0.11% - 0.03% following cataract surgery, intravitreal injection, and vitrectomy, respectively (Soliman et al., PMID 32467482). Initial management of exogenous endophthalmitis consists of intravitreal antibiotics (usually vancomycin and ceftazidime) +/- intravitreal steroids. Based on results from the Endophthalmitis Vitrectomy Study from 1995, criteria for vitrect...