Do you routinely recommend proton therapy for whole ventricular radiation for intracranial germinoma after chemotherapy?
2 Answers
Mednet Member
Radiation Oncology · Cleveland Clinic
The pattern of failure data from SIOP GCT '96 (Calaminus et al., PMID 23460321) and the SFOP-90 experience (Alapetite et al., PMID 20716594) in which patients with localized CNS germinoma were treated with induction chemotherapy followed by focal radiotherapy was predominantly intraventricular. Ther...
Mednet Member
Radiation Oncology · Essen University Hospital
According to the European Concept after complete response to chemotherapy WVI with 24 Gy would be administered; early results seem to confirm effectiveness (NCT01424839 - not yet published). A local boost is required (16 Gy) after WVI in case of an incomplete response to chemotherapy. This is typica...