Do you routinely use mannitol to prevent cisplatin-induced nephrotoxicity?

Topics: Head and Neck Cancers • Gynecologic Cancers • Genitourinary Cancers • Bladder Cancer • Medical Oncology • Supportive Care

If so, do you use it for all patients or only cisplatin doses >= 70 mg/m2? What dose of mannitol do you use?

Answer from: Medical Oncologist at Academic Institution

Having treated thousands of patients over the past several decades, we NEVER use mannitol nor do we find any logic for its administration in patients getting appropriate pre-chemo and post cisplatin saline hydration.

Comments

Medical Oncologist at University of Washington School of Medicine
Agree with Dr. @Lawrence H. Einhorn, we don’...

Answer from: Medical Oncologist at Community Practice

Studies on mannitol efficacy in reducing cisplatin-induced nephrotoxicity have reported conflicting results. Mannitol is an osmotic diuretic and has been used in the past for the prevention of cisplatin-induced nephrotoxicity with the rationale that it could reduce the half-life of cisplatin in the ...

Comments

at ProMedica Toledo Hospital
Dr. Einhorn has more experience with platinum...

Answer from: Medical Oncologist at Academic Institution

I agree. Having treated many patients over the years without mannitol, we have never encountered renal failure. I confer with the others who have posted comments; I would not recommend its use.

Answer from: at Community Practice

I never used mannitol in these patients and only give good hydration.

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