Do you screen for MTHFR polymorphisms in your patients with treatment-resistant depression?

In the trial by Papakostas et al., PMID 23212058, we have shown that adjunctive L-methylfolate at 15 mg/day had significantly greater efficacy compared with continued SSRI therapy plus placebo on both primary outcome measures (response rate and degree of change in depression symptom score) and two s...

We are not doing it routinely. The first part is to thoroughly examine the history of treatment failures and determine if it meets the criteria of treatment-resistant depression. If none of the typical medications and therapies have provided optimal relief, this can be run after explaining all the b...