I do not screen ALS patients routinely for PNP antibodies because I do not believe true paraneoplastic ALS exists as a disease entity. The few rare paraneoplastic motor neuron syndromes I am aware of are very different from typical ALS- either a purely UMN syndrome resembling PLS which has been desc...

A 2015 article in research gate described testing 316 patients with MND of which 44% had Mayo paraneoplastic antibody panel done. 13 of the 138 patients tested (9%) had at least 1 paraneoplastic antibody. A 2022 article in Brain Science described a patient with MND with anti SOX1 and anti Gad65 anti...