Do you send CSF or serum ACE levels in the workup of neurosarcoidosis?

Unfortunately, serum and/or CSF ACE levels are just not sensitive or specific enough to guide the diagnosis or treatment of sarcoidosis, particularly neurosarcoid. Rather, imaging characteristics, specific organ system involvement, and biopsy results are much more useful in my practice.

Bradshaw et a...

If you are working up for neurosarcoidosis, then ACE levels are included.

I agree with Dr. @Dr. First Last.

Also worth mentioning a paper from 2019 which suggested improved sensitivity and specificity of sIL-2R (soluble interleukin-2 receptor) compared to ACE as an alternative biomarker for the diagnosis of sarcoidosis (Eurelings et al, PMID 31622413). Additionally, a 202...