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Do you start steroid therapy in a patient with pure ARDS without septic shock, or would you only consider steroids only in those with severe community acquired pneumonia?

To help interpret clinical applications of the CAPE COD (2023) and DEXA ARDS (2020) trials.
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Do you start steroid therapy in a patient with pure ARDS without septic shock?

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2 Answers
Mednet Member
Mednet Member
Pulmonology · University of Pittsburgh School of Medicine
Answered on

I do not routinely start corticosteroids for pure ARDS, septic shock, or severe community-acquired pneumonia. In my mind, the DEXA-ARDS study was underpowered to answer the question. The recently published ESCAPE and CAPE-COD trials yielded conflicting results in CAP. In my mind, before adopting cor...

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Mednet Member
Mednet MemberInvited Expert
Pulmonology · Cleveland Clinic
Answered on

I agree with the above comment, this is a complex answer and right now further studies need to be conducted to determine if routine steroids should be considered in all three disease states.

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