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Do you still recommend consolidative allogeneic stem cell transplants for patients with Richter transformation in CR after frontline treatment in the modern era of therapies?
Given availability now for CAR-T, non covalent BTKi, CD20/CD3 bispecific antibodies
Answer from: Medical Oncologist at Academic Institution
The optimal treatment of diffuse large B-cell lymphoma (DLBCL) emerging in the context of underlying chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) (e.g. Richter’s syndrome) is an area of ongoing debate. For initial treatment, I typically administer standard DLBCL chemoimm...
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Answer from: Medical Oncologist at Community Practice
The question of consolidative allogeneic stem cell transplant for Richter's transformation in a world where we have CAR T-cell therapy is incredibly controversial. Multicenter studies have shown that there is a significant subset of patients with long-term durable remissions post CAR T cells without...
Answer from: at Academic Institution
Because of the morbidity and mortality associated with allogeneic stem cell transplant and the availability of newer therapies for R/R disease (CAR-T, BTK inhibitors, bispecific antibodies), I generally do not recommend allogeneic transplant in first remission for patients with Richter transformatio...