Do you stop hydroxyurea or switch to an alternative therapy in a male patient with controlled Hb SC disease who is interested in having children?  

Part of the reason the patient may have controlled disease could be the hydroxyurea and so stopping that therapy might not be best for the patient's disease. Also, many patients on hydroxyurea can still get their partner pregnant. So, I would only consider stopping/holding it if the patient is havin...

I would stop hydroxyurea. As far as alternative therapies, there were either no, or very few patients with HbSC disease in the trials of l-glutamine, voxelotor, and crizanlizumab, the three other FDA-approved drugs for sickle cell disease, so the benefits and risks for these agents in this genotype ...