Do you switch to an alternative agent for C difficile colitis for a patient with suspected infection and positive testing who continues to have >3 watery bowel movements daily despite multiple days of oral vancomycin treatment?

The question about switching to another agent for Clostridioides difficile (Cdif) colitis in a patient who tests positive for Cdif but continues to have diarrhea despite multiple days of oral vancomycin treatment does not include any information regarding the clinical status of the patient, the pres...

I don't know if all nucleic acid-based tests for C. difficile are quantitative, but the most commonly used tested is cobas C. diff by Roche. The test results are reported qualitatively for some reason. Y'all have gotten used to cycle thresholds, but I, in a former life, ran thousands of RT-Q-PCR ass...