Do you treat 45 mg/day as a practical ceiling before switching strategies in a child with ADHD and incomplete methylphenidate response?

This is a very good question, and generally, the guidelines are not clear. In clinical practice, I almost never prescribe more than 45 mg/day of methylphenidate for a patient. Some sources recommend not exceeding 60 mg/day for immediate-release methylphenidate, and others set the limit at 72 mg/day ...

There is significant variability in the bioavailability of different methylphenidate formulations, particularly in children, which can contribute to a wide range of dosing requirements and may occasionally necessitate doses beyond standard FDA-approved recommendations. In such situations, close moni...