Do you treat low 25-OH vitamin D levels in those with end stage kidney disease?

Low 25-OH vitamin D levels in those with end-stage kidney disease should absolutely be treated. The assumption that calcitriol administration satisfies all the vitamin D needs of the body is incorrect. While it is true regarding the endocrine effects of calcitriol (calcium and phosphate homeostasis) it ignores the hormone's very important intracrine effects. 25-OH vitamin D enters a variety of cells in the body where localized production of calcitriol takes place; this occurs via a different rou...