Do you treat with high-dose radiation alone (without ADT) for favorable intermediate risk prostate cancer?
We do treat so-called low-intermediate risk prostate cancer with RT alone (brachy alone or high dose IMRT). The critetia we use is GS 3+4, low number of cores being positive, non-palpable disease, and PSA close to 10.
The impact of short term androgen ablation with high dose RT is not clearly defined...
This is an interesting question, since the randomized data supporting the use of ADT for intermediate risk patients used RT doses that would be considered low by today's standards. Some interesting retrospective data and post hoc analysis of randomized data would suggest that certain patients with s...
The following may be useful for readers of this thread:
Cancer. 2014 Jun 15;120(12):1787-93. doi: 10.1002/cncr.28609. Epub 2014 Mar 6.
The likelihood of death from prostate cancer in men with favorable or unfavorable intermediate-risk disease.
Keane FK1, Chen MH, Zhang D, Loffredo MJ, Kantoff PW, Rens...