Do you use FVIII levels to differentiate between DIC and coagulopathy of liver disease?  

Common thought is that FVIII may be used for differentiating coagulopathy in liver disease (normal to increased, from reduced clearance of VWF/FVIII) from DIC (reduced, from consumption).

However, the counterpoint is that as an acute phase reactant, FVIII may be increased in DIC. 

There are some older trials, demonstrating both these contradictory findings (Corrigan Jr. et al., PMID 4758284 vs. Spero et al., PMID 6773170). If baseline levels of FVIII are known, that may be helpful to establish a change. 

Do you use FVIII levels for this indication in your clinical practice?

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Answer from: at Academic Institution