Do you use immune checkpoint inhibitors in NSCLC patients with pre-existing, well-controlled autoimmune disease?
Does the type of autoimmune disease (ex IBD, rheumatoid arthritis, interstitial lung disease) matter?
Answer from: Medical Oncologist at Academic Institution
While there is limited data on the use of PD1 inhibitors in patients with pre-existing autoimmune conditions; in patients with metastatic NSCLC with limited options, it warrants consideration. This is obviously a high risk population to treat and close monitoring and co-ordinated care with specialis...
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Answer from: at Community Practice
This is a great question - there should not be a blanket withholding of checkpoint inhibitor therapy for patients with pre-existing autoimmune diseases. If immune checkpoint inhibitors (ICIs) are the next best option for the patient's malignancy, having control of the pre-existing autoimmune disease...